Mean accumulated number of MetS components was the highest in the highest HOMA-IR-lowest serum HMW adiponectin quartile group and lowest in the lowest HOMA-IR-highest serum HMW adiponectin quartile group, while HOMA-IR appears to be a more dominant determinant for MetS components than serum HMW adiponectin. This evidence concerns the gene ADIPOQ and metabolic syndrome.