Kimm et al. [33] demonstrated that the lipid ratios of TC/HDL-C, LDL-C/HDL-C and TG/HDL-C, as well as TG and HDL-C, were each consistently associated with the number of metabolic syndrome components, insulin resistance quartiles (based on homeostatic model assessment), and log-transformed adiponectin quartiles. The gene discussed is ADIPOQ; the disease is metabolic syndrome.