Because VEGF has been shown to play a major role in macular edema and retinal neovascularization (RN) [4, 5] although other factors may be involved as well [9, 11] anti-VEGF treatments have been hypothesized as an alternative adjunctive treatment for DME [12, 13] and RN [14–16]. This evidence concerns the gene VEGFA and macular retinal edema.