IL10 and infection: Indeed, a picture is emerging in which infection with helminth parasites leads to a general dampening of host immunity or the creation of an immuno-regulatory environment (dominated by IL-10, transforming-growth factor (TGF-β), regulatory T cells, and alternatively activated macrophages) that can explain the seemingly paradoxical observation that the “helminth therapy” may reduce Th2-dominated conditions such as allergy and atopy [1, 2].