CD4 and diabetes mellitus: In view of the fact that in case of diabetes only subpopulation of Tregs that carries CD62L has high suppressive activity [13, 15], we can suspect that the lower percentage of CD4+CD25highCD62Lhighcells among peripheral blood Tregs as well as the expression of CD62L on CD62Lhigh Tregs in DM1 group may be associated with defect in the homing capabilities of this cell population, as CD62L is responsible for migration of Tregs to secondary lymphoid tissues [13].