AKT1 and non-Hodgkin lymphoma: Approximately 85% of Non-Hodgkin lymphoma (NHL) s arise from cells of B-cell lineage.[39] mTOR signaling is activated in Hodgkin lymphoma cell lines and primary tumors.[40] Cyclin D1 overexpression is a characteristic feature of mantle cell lymphomas.[41] PI3K and Akt overexpression is frequently observed in several B-cell lymphomas.[42]