Possibly, our group observed a higher rate of CCND2 hypermethylation in both cancerous and cancer-free lung tissues because we used MethyLight assays instead of methylation-specific PCR (MSP), which was used by Virmani et al. Thus, we may have detected low levels of hypermethylated genes in cancer-free tissues which were not detected by MSP. This evidence concerns the gene CCND2 and cancer.