CCND2 and diffuse large B-cell lymphoma: Interestingly, while CCND2 hypermethylation (and therefore low CCND2 protein expression) has been associated with poor prognosis in epithelial ovarian cell cancer [55] and recurrence of hepatocellular carcinoma [56], increased CCND2 expression has been associated with poor prognosis in diffuse large B-cell lymphoma [57].