SPP1 and ovarian carcinoma: Markers such as interleukins 6 and 8, lysophosphatidic acid, eosinophil-derived neurotoxin and COOH-osteopontin fragments, apolipoprotein A1, and transthyretin have mostly noted large increases in sensitivity and specificity in several forms of ovarian cancer [41, 46, 79, 80].