RB1 and neoplasm: These tumours show frequent alterations of genes involved in cell cycle control or apoptosis including k-RAS, EGFR, c-Myc, cyclin D1 (CCND1), TP53, retinoblastoma (Rb), p16INK and Bcl2 [3], but the relevant molecular mechanisms driving the aggressive biological behaviour of these tumours are largely unknown.