ADSS2 and schizophrenia: While the influence of prolonged NMDA receptor hypofunction on the functional activity of this specific enzyme remains to be confirmed, and clearly warrants further systematic investigation, the recent finding of altered ADSS gene expression in schizophrenia [65] and the association of ADSS gene polymorphisms with schizophrenia [66] further highlights a potential role for this metabolic pathway in this disorder.