As shown in Figure 2, when the cases were divided by the histological response grade according to the definitions in the Japanese Classification of Colorectal Carcinoma, the density of CD4(+) T cells was 68.7 ± 27.3/field in 27 cases of grade 1 and 89.6 ± 34.0/field in 13 cases of grade 2. The gene discussed is CD4; the disease is colorectal carcinoma.