ESR1 and cancer: As part of our research endeavor to explore the potential of using zebrafish for modeling estrogen-related cancer research (such as estrogen-induced carcinogenesis, estrogen-responsive cancer model and for screening of estrogen receptor modulators), we performed microarray experiments on zebrafish exposed to estrogen 17β-estradiol (E2) and, a combination of E2 and anti-estrogen ICI 182,780 (E2+ICI).