Thus, in an in vitro study of pig coronary subendocardial arterioles two weeks after myocardial infarction an increased vasoconstrictor response to ET-1 was observed in vessels from animals with myocardial infarction compared to vessels from control animals [32], and an increased vasoconstriction to endothelin was found in the coronary arteries after ischemia-reperfusion of the porcine heart [33]. This evidence concerns the gene EDN1 and myocardial infarction.