We observed a significant decrease in the expression levels of TNF-α, TNFR1, TRADD and TRAF2 and immunoprecipitation experiments revealed inhibited interaction of TRADD-TRAF2 and along with increased FADD expression levels in pM-treated 4910 and 5310 glioma xenograft cells. This evidence concerns the gene TNFRSF1A and central nervous system cancer.