NHLH2 and neuroblastoma: Since neuroblastoma is one of the most common childhood solid tumors of peripheral nervous system arising from as yet unidentified population of neural crest cells [22] and Mash1 regulates proliferation of the sympathetic nervous system [23], it is likely that deregulated expression of Mash1 could contribute to genesis and development of neuroblastoma, which might be regulated by LMO3/HEN2 transcriptional complex both in vitro and in vivo.