LMO3 formed a complex with neuronal-specific basic helix-loop-helix (bHLH) transcription factor HEN2, which was also expressed at higher levels in unfavorable neuroblastoma than favorable one, raising a possibility that LMO3 may form a complex with HEN2 and play an important role in genesis and development of neuroblastoma through transcriptional regulation of as yet unidentified target gene(s). Here, LMO3 is linked to neuroblastoma.