Thus, it is likely that the LMO3 complex including HEN2 and HES1 regulates transcription of Mash1. The mRNA expression pattern of LMO3, HEN2, Mash1 and HES1, a negative regulator of Mash1 transcription, in neuroblastoma cell lines is shown in Figure S2. The gene discussed is NHLH2; the disease is neuroblastoma.