We have previously shown that recombinant EBV deleted for the gene encoding the major glycoprotein (gp350) that binds to CD21 on B cells, can directly infect epithelial cells [11]; although less efficient that transfer infection with wild-type EBV, direct infection with cell-free Δgp350 recombinant virus is substantially more efficient than direct infection with wild-type EBV. This evidence concerns the gene CR2 and infection.