MYC and hepatocellular carcinoma: A mouse model of human HCC with inducible expression of MYC in adult liver cells has shown that overexpression of MYC is sufficient to initiate HCC development; however, these tumors develop with a prolonged latency, suggesting that other genetic alterations are necessary to generate HCC, including mutations in the p53 pathway [32], [37], [38], [39], [40].