MAPT and tauopathy: The finding that DYRK1A is involved in the phosphorylation of sites that control key microtubule binding functions of tau (S262, T231), as well as sites that are phosphorylated relatively late during the formation of neurofibrillary tangles (S396, S404), raises the interesting possibility that DYRK1A could be an important site of regulatory control for tau function and for the formation of tau pathology during the progression of tauopathies.