The anti-inflammatory and beneficial effect of type I interferons such as IFN-α and IFN-β in autoimmune diseases such as multiple sclerosis and uveitis [2], [3], [25]–[27] contrasts with a pro-inflammatory role for IFN-α in systemic lupus erythematosus and dermatomyositis [33]-[34]. Here, IFNB1 is linked to autoimmune disease.