The G3460A/ND1 mutation affects a more restricted number of LHON patients and is frequently heteroplasmic.3 The G11778A/ND4 and T14484C/ND6 changes are the most frequent LHON mutations and are mostly homoplasmic; spontaneous visual recovery often occurs with the T14484C/ND6 mutation. The gene discussed is MT-ND4; the disease is Leber hereditary optic neuropathy.