Since heterozygous missense mutation in the highly conserved gene UBIAD1 was first associated with the disorder,4, 5 at least 21 different missense mutations have been reported to underlie SCD in 40 mostly Western and Asian families.4–11 We describe an affected family from the Arabian Peninsula and document that heterozygous missense UBIAD1 mutation segregated with the phenotype. This evidence concerns the gene UBIAD1 and Schnyder corneal dystrophy.