UBIAD1 is a highly conserved gene across vertebrates and invertebrate orthologs.4, 5, 11 Residues 58-333 contain a prenyltransferase domain for which the bacterial archetype is bacterial protein UbiA.4, 5, 11 All reported mutations associated with SCD to date fall within this domain.4–11 The protein may play a direct role in intracellular cholesterol biochemistry and/or prenylation of other proteins regulating cholesterol transport and storage. Here, UBIAD1 is linked to Schnyder corneal dystrophy.