TP53 and melanoma: UV-B or HPV could induce stem cell gene p53 (tumor suppressor gene) mutations and transformation into malignancy.19, 23 Hence a lesion that increases in size on the bulbar conjunctival should be considered for biopsy because of a have high incidence of malignant melanoma.18 However, most lesions of the caruncle were benign with exception lymphoid hyperplasia that may progress to malignant lymphoma.