LOXL1 and glaucoma: Following this discovery, multiple replication studies in populations from the United States,21–25 Australia,26 Europe,27–30 Japan,31–36 China,37, 38 and India39 confirmed genetic susceptibility of LOXL1 polymorphisms to PEX syndrome/glaucoma and verified the LOXL1 gene as a principal genetic risk factor for this condition worldwide accounting for almost all PEX cases.