It has been suggested that congenital glaucoma and juvenile glaucoma are allelic variants of CYP1B1 and that CYP1B1 and MYOC might act through common biochemical pathways with CYP1B1 acting as a modifier for MYOC. 58 Digenic interactions of MYOC and CYP1B1 alleles have also been reported in cases of PCG.59 This evidence concerns the gene MYOC and congenital glaucoma.