It has been observed that mice lacking both CYP1B1 and Tyr had severe iridocorneal angle malformations than those lacking only CYP1B1. 26 Also some albinos are reported to have anterior segment dysgenesis and congenital glaucoma suggesting the possible role of Tyr in congenital glaucoma. This evidence concerns the gene CYP1B1 and congenital glaucoma.