Given that both ITGA5 and ITGB6 genes, as well as the TGFB1 gene are components of the human airway basal cell signature, it is possible that ITGA5+ ITGB6+ cells represent a airway basal cell population that regulate their own TGF-β signaling in an autocrine manner, potentially contributing to local control of inflammation and lung fibrosis [77]. The gene discussed is ITGA5; the disease is pulmonary fibrosis.