ANXA2 and Patent ductus arteriosus: To determine whether the change in ANXA2 localization that occurs as a result ofTyr23 phosphorylation affects the invasion capacity of PDA cells, a set ofplasmids that express exogenous FLAG-tagged ANXA2 includingANXA2WT-FLAG, ANXA2Y23A-FLAG, andANXA2Y23E-FLAG were developed.