Thus, thehemisplenectomy model was again employed to examine whether Tyr23phosphorylation of ANXA2 is required for ANXA2-mediated murine PDA metastases.Mice injected with Panc02 cells stably expressing exogenous ANXA2Y23Asurvived significantly longer than mice injected with Panc02 cells stablyexpressing exogenous ANXA2WT (p = 0.001) (Figure 4F). This evidence concerns the gene ANXA2 and Patent ductus arteriosus.