CYP1A2 and Global developmental delay: This means that a highly exposed mother with genetic resistance (i.e., high levels of hepatic CYP1A2, both basal and PCB induced) might have a normal child, whereas a less exposed mother who is genetically susceptible (with low levels of hepatic CYP1A2, both basal and PCB induced) could have a child with developmental delays despite lower PCB exposure.