所用英文检索词为:non small cell lung cancer、non small cell lung、carcinoma、lung alveolus cell carcinoma、lung adenocarcinoma、NSCLC;drug therapy、antiangiogenic、antiangiogenesis、adjuvant therapy、combination therapy、endostatin、rh-endostatin、chemotherapy。中文检索词为:化疗、恩度、内皮抑素、重组人血管内皮抑素、抗血管生成治疗、靶向药物、肿瘤血管、肺癌、肺肿瘤、非小细胞肺癌。文献类型为:systematic reviews、meta-analyses、major clinical studies、randomized controlled trials (RCT)、practice guidelines。. This evidence concerns the gene COL18A1 and non-small cell lung carcinoma.