HMGB1 and systemic lupus erythematosus: Based on this hypothesis, it is suggested that progression and flares of lupus are due to increased production of pro-inflammatory molecules IL-6, TNF-α, MIF (macrophage migration inhibitory factor), HMGB1 (high mobility group box 1), free radicals and lipid mediators such as prostaglandins (PGs), leukotrienes (LTs) and/or decreased formation and release of anti-inflammatory molecules: IL-4, IL-10, TGF-β, and lipoxins, resolvins, protectins, maresins and nitrolipids.