Then Jamain et al.[16] first demonstrated the evidence for a pathogenic effect of neuroligins in ASDs, who identified a missense mutation (R451C) in NLGN3 and a frameshift mutation (1186insT) in the homologous gene NLGN4X in two Swedish families in each case one brother with typical autism and the other with Asperger Syndrome. Here, NLGN4X is linked to autism.