We could concluded that the mechanism by which HFD could affect brain dysfunction is by rising obesity indicators, lipid profile (TG, TC, LDL) and disturbing the metabolic parameters (CK, γGT, uric acid and glucose in blood) that correlated with BChE and associated with BOS marker (brain MDA and catalase) and reduction of brain NO resulting in brain lipid peroxidation, cerebrovascular changes and consequently dysfunction and susceptible to disease as AD while G. Cambogia as antiobesity and antioxidant agent rearrange these changes. Here, CAT is linked to obesity due to melanocortin 4 receptor deficiency.