This study provide persuasive evidence for the presence of brain endothelial dysfunction in obesity which associated with high abdominal fat, hyperglycemia, hypertriglyceridemia, hypercholesterolemia, abnormalities of LDL, high BChE, γGT activity and brain oxidative stress as a potential factors leading to endothelial dysfunction. The gene discussed is BCHE; the disease is endothelial dysfunction.