A similar statistically significant 2- to 4-fold increase in the degree of apoptosis was observed after knockdown of ARHGDIA (siRNA1 P = 1.5 × 10-6, siRNA2 P = 1.2 × 10-8, siRNA3 P = 5.5 × 10-9), COBLL1 (siRNA1 P = 1.3 × 10-5, siRNA2 P = 1.8 × 10-5, siRNA3 P = 0.00063), and TM4SF1 (siRNA1 P = 7.3 × 10-5, siRNA2 P = 5.3 × 10-5, siRNA3 P = 3.2 × 10-5), but not PKM2, in tumor cells (Figure 3B). This evidence concerns the gene COBLL1 and neoplasm.