For example, the fact that two of the genes (TM4SF1, COBLL1) are molecular markers for relatively good prognosis patients while the other one gene (ARHGDIA) is a molecular marker for relatively poor prognosis patients suggest that therapies could be tailored and tested in a rational manner to target specific pathways activated in different mesothelioma subsets. The gene discussed is TM4SF1; the disease is mesothelioma.