Employing various immunohistochemical antibodies, such as CD10, CD138, anti-Bcl-2, anti-Bcl-6, MUM1 and anti-p53, several groups have tried to sub-classify DLBCL into the germinal center B-cell-like DLBCL (GCB-DLBCL) and activated B-cell-like DLBCL (ABC-DLBCL) sub-groups, with comparable differences in clinical behavior [16]. The gene discussed is BCL6; the disease is diffuse large B-cell lymphoma.