Our case had to be differentiated from other variants of DLBCL, such as T-cell histiocyte-rich large B-cell lymphoma (TCHRLBCL), which shows CD20+, CD30-, CD15-, almost no small CD20+ or immunoglobulin D-positive (IgD+) B-cells and often more CD8+ than CD4+ T-cells in the background. This evidence concerns the gene CD4 and diffuse large B-cell lymphoma.