It has become clear that the "double-hit" cases (the combination of a c-Myc breakpoint with mostly BCL2 breakpoints and other recurrent chromosomal breakpoints), often with distinct morphological features of BL, should fall into a novel category of "B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and BL." The gene discussed is MYC; the disease is B-cell non-Hodgkin lymphoma.