It has become clear that the "double-hit" cases (the combination of a c-Myc breakpoint with mostly BCL2 breakpoints and other recurrent chromosomal breakpoints), often with distinct morphological features of BL, should fall into a novel category of "B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and BL." This evidence concerns the gene MYC and diffuse large B-cell lymphoma.