When we analyzed the combined presence of DRB1*1501 and absence of DPB1*0401, we found this combination had an even higher risk to anti-GBM disease (p = 2.0 × 10-12) than HLA-DRB1*1501 alone (p = 1.6 × 10-7). The gene discussed is HLA-DPB1; the disease is glioblastoma.