The present study demonstrated that the intravenous administration of PDTC had partial therapeutic effects on endotoxemia-induced lung tissue edema and damage, neutrophil influx to the lung, alveolar-capillary barrier dysfunction, and high systemic levels of TNF-α and ICAM-1 as well as over-activation of NF-κB. Here, NFKB1 is linked to serum lipopolysaccharide activity.