The elevated CSF VEGF-A in ALS indicates possible presymptomatic initiation of pathological events and intrathecal production from degenerating motor neurons, which is contrary to existing study where decreased VEGF-A165 dependent neuroprotection in ALS, due to reduced CSF VEGF-A, has been suggested [15]. The gene discussed is VEGFA; the disease is amyotrophic lateral sclerosis.