Due to its potential to inhibit critical receptor tyrosine kinases involved in HCC progression via the IGF-1 signaling pathway and NF-κB, we conclude that L.obtusiloba extract or its active compounds represent a useful tool in a rational complementary approach e.g. with sorafenib for treatment of HCC or as cancer preventive agents. Here, NTRK1 is linked to hepatocellular carcinoma.