First, RVL inhibited hepatic secretion of IL-18 induced by liver-infiltrating melanoma cells; second, it prevented IL-18-dependent VCAM-1 expression on the hepatic microvasculature which decreased by 50% the microvascular retention of melanoma cells in the liver; and third, it prevented melanoma cell responses to hepatic IL-18, further affecting VLA-4-dependent melanoma cell adhesion and proliferation. The gene discussed is VCAM1; the disease is melanoma.