TFR2 and anemia (phenotype): Other rare genetic causes of high ferritin levels with effective iron overload in pediatric age include: aceruloplasminemia, which is characterized by a lack of ceruloplasmin, anemia and the development of iron overload, with neurological symptoms related to the deposition of iron in the cerebral tissues [16]; transferrin receptor 2-related hemochromatosis, which can sometimes have its onset before adulthood [17]; atrasferrinemia and hypotransferrinemia, in which hemosiderosis is accompanied by hypochromic microcytic anemia [18].