By contrast, the most common cause of genetic hyperferritinemia with iron overload is hereditary hemochromatosis, which is caused by the mutation of the HFE gene [15]; the difference with both hyperferritinemia-cataract syndrome and juvenile hemochromatosis is that high ferritin levels in hereditary hemochromatosis cannot be seen in pediatric age, because iron overload develops through adulthood. Here, HFE is linked to isolated hyperferritinemia.