These results indicate that the SLC35C/E lineage, which contains SLC35C1-2 transporters necessary for fucosylation of the Notch receptor [12], and the SLC35E1-4 transporters known to function as oncogenes/tumor suppressor genes in e.g. neuroblastoma [13] and glioblastoma [14], was probably formed in Animalia. TMEM22, from the "AMAC" subfamily, is also involved in cancer [38]. Here, SLC35G2 is linked to cancer.