History of cardiovascular disease 1.42 (0.66,3.0.8), obesity 0.77 (0.48,1.25), LDL cholesterol mg/dL 1.0 (0.9, 1.01), smoking 1.11 (0.63, 1.97) and CRP levels (mg/dL) 0.96 (0.81, 1.14) were not independent predictor in this model. This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.