We have previously demonstrated an association between a single nucleotide polymorphism rs2808630 in the CRP gene and CKD progression in the prospective African American Study of Kidney Disease and Hypertension (AASK) study [11], a randomized control trial designed to evaluate the effect of three different antihypertensive medications in the progression of hypertensive kidney disease [20]. The gene discussed is CRP; the disease is chronic kidney disease.