The CHEK2-Breast Cancer Consortium reported a frequency of 5.1% for the CHEK2*1100delC variant in familial breast cancer cases who tested negative for BRCA1 and BRCA2 (Breast cancer 2, early onset) mutations, as opposed to 1.1% of carriers in the control population [3]. The gene discussed is BRCA2; the disease is breast carcinoma.