PDE4D and lung cancer: When Weir et al. [21] analyzed this lung cancer data set using the GISTIC approach, they identified five deleted focal regions and 17 amplified focal regions with statistical significance: in these regions, ten known oncogenes (MDM2, MYC, EGFR, CDK4, KRAS, CCNE1, ERBB2, CCND1, TERT, and ARNT), two known tumor suppressor genes (CDKN2A and PTEN), and six new candidate genes (MBIP, NKX2-1, VEGFA, PTPRD, PDE4D, and AUTS2) were found.