Among the 18 cancer related genes noted above, six known oncogenes (MDM2, EGFR, KRAS, CCNE1, ERBB2, and CCND1), one known tumor suppressor gene (CDKN2A), and three new candidate genes (MBIP, NKX2-1, and VEGFA) are included in the focal aberrations. The gene discussed is NKX2-1; the disease is cancer.