Furthermore, strong complementarities between the early stage and late stages of infection was found, showing a prominence of metabolic and stress signals in the early stage and of the immune response related to the lipid metabolism in the late stage, Both mechanisms were apparently triggered by a small number of genes, including XBP1 and SREBF1. The cattle-specific response showed an intensification of the immune and inflammatory responses through T lymphocyte involvement. This evidence concerns the gene XBP1 and infection.