The forced expression of LPP3 in NIH-3T3 fibroblast cells did not transform these cells (data not shown), suggesting that the LPP3 is not tumorigenic, but in combination with genetic instability such as the mutation of APC, elevated expression of LPP3 potentiates tumor progression by stimulating β-catenin and CYCLIN-D1 transcriptional activity. The gene discussed is CCND1; the disease is neoplasm.