The 324 genes were further investigated using functional information, molecular interactions and promoter analysis revealing over-represented motifs of four transcription factors: RUNX1, E2F1, STAF/PAX2 and STAT3. In order to test the relevance of the 324 genes for more general brain phenotypes we used independent publicly available data on cerebral pathologies not related to DS and identified a subset of 79 DS genes that were differentially expressed in these studies. The gene discussed is STAT3; the disease is Dravet syndrome.