TARDBP and amyotrophic lateral sclerosis: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) caused by frontotemporal lobar degeneration with ubiquitin and transactive response DNA binding protein 43 (TDP-43) positive inclusions (FTLD-TDP) represent two different manifestations of the same neurodegenerative disease [1].