TARDBP and proteostasis deficiencies: The distribution of histopathological changes in particular TDP-43 immunoreactive profiles involved subcortical and brainstem structures somewhat more than reported previously, in association with FTLD-TDP subtypes [24], supporting the notion that TDP-43 proteinopathies are representatives of a multisystem proteinopathy [25] with involvement of anatomical regions corresponding to predominant clinical symptoms.