Furthermore, these clinical phenotypes were reported in cases with an established genetic cause, linked not only to PGRN mutations but also to mutations in TARDBP. MND, FTLD-MND, and FTD with supranuclear palsy having also been associated with TARDBP variations [34-36], demonstrating the complexity of clinico-pathological and genetic relations. Here, GRN is linked to mild neurocognitive disorder.