Adverse events leading to discontinuation in the 5 placebo-treated subjects were: increased alanine aminotransferase and increased aspartate aminotransferase (1 subject); nausea and vomiting (1 subject); delusional disorder-persecutory type, musculoskeletal stiffness, and tremor (1 subject); anxiety and schizophrenia (1 subject); and insomnia and schizophrenia (1 subject). The gene discussed is GPT; the disease is insomnia.