Moreover, cyclo-oxygenase-2 activation appears to play an important role in the development of cardiac autonomic neuropathy, as cyclooxygenase-2 gene inactivation is protective against indexes of cardiac autonomic neuropathy, oxidative stress and inflammation and prevents left ventricular dysfunction and myocardial fibrosis in experimental diabetes [48]. Here, PTGS2 is linked to Myocardial fibrosis.