IL6 and Cachexia: Cytokines play a key role in ageing56 and are central factors in the pathogenesis of cachexia.57–59 Increased CRP-values, an induction product produced in the liver by interleukin-6,60 and proinflammatory cytokines like interleukin-6 were associated with the presence of frailty.61–63 Thus, these immune mediators possibly contribute to aggravating the comorbidities of these patients and to an increase in frailty.64