Stimulation of this receptor promotes the secretion of VEGF by endothelial cells, and inhibition of S1P with a blocking antibody prevents the release of IL6, IL8 and VEGF by tumor cells, suggesting that S1P production and S1P1 activation are required to elicit an angiogenic response (Dorsam and Gutking, 2007). This evidence concerns the gene MBTPS1 and neoplasm.