ASAH1 and Familial prostate cancer: In this connection, human acid ceramidase has been shown to be overexpressed, although not mutated, in 42% prostate cancer specimens and in three prostate cancer cell lines (Seelan et al. 2000) and inhibition of ceramidase activity with aromatic ceramide analogues showed effective anticancer activity in melanoma and colon cancer cells (Raisova et al. 2002; Selzner et al. 2001).